Spectinomycin resistance mutations in chloroplast 16S ribosomal RNA

Mutations in the 16S rRNA conferring spectinomycin resistance map to a conserved stem region in the 3' portion of the RNA. All the mutants whose sequence is known destroy an AatII site in this region.

Allele: spr-u-1-6-2
(A>G at nt1123, equivalent to E. coli nt1191; this mutation confers high level spectinomycin resistance under all growth conditions)
Strains:

Allele: spr-u-1-H-4
(Identical mutation to spr-u-1-6-2, A>G at nt1123, equivalent to E. coli nt1191; this mutation confers high level spectinomycin resistance under all growth conditions)
Strains:
Allele: spr-u-sp-23
(A>C at nt1123, equivalent to E. coli nt1191; this mutation confers high level spectinomycin resistance under all growth conditions)
Strains:
Allele: spr-u-1-27-3
(G>A at nt1125, equivalent to E. coli nt1193; confers relatively low levels of spectinomycin resistance. Cells of this mutant grown on minimal medium on agar are killed by 100 micrograms/ml spectinomycin but will grow on acetate at this concentration)
Strains:
Allele: spr-u-1-5-2
(Not sequenced, but mutation destroys AatII site in 16S rRNA gene)
Strains:
For more information on Chlamydomonas mutants, see the Allele category in ChlamyDB.


Return to : [ core collection list | on-line order form | strains home page | Chlamydomonas Genetics Center ]